El núcleo subtalámico y su potencial utilidad como blanco de estimulación cerebral profunda en trastorno obsesivo-compulsivo

Fabián Cremaschi; Lucas Serrano

doi:10.47924/neurotarget2011280

Authors

Fabián Cremaschi Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina.
Lucas Serrano Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina.

DOI:

https://doi.org/10.47924/neurotarget2011280

Keywords:

Obsessive-compulsive disorder, subthalamic nucleus, deep brain stimulation

Abstract

The obsessive-compulsive disorder (OCD) represents a neuropsychiatric disease, in which the existence of a certain number of patiens with severe symptoms and resistant to the conventional pharmacological and psychological approach motivates the search of alternative therapies. In this regard, surgical subthalamic nucleus (STN) stimulation has been postulated as a possible treatment for these patients, given the fundamental role of this structure in limbic-motor integration within the fronto striatal pathways and its relationship with OCD pathophysiology. Therefore, the aim of the present article is to present the updated clinical evidence related to STN- stimulation efficacy, as well as to raise the issue about the possible adverse psychiatric events that should be carefully assessed in further studies.

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