Stereotactic radiofrequency thermolesion for disconnection in Hypothalamic Hamartoma due to gelastic crises refractory to previous surgical interventions.

Authors

DOI:

https://doi.org/10.47924/neurotarget2024465

Keywords:

hypothalamic hamartomas, gelastic crises, radiofrequency thermolesion, stereotactic

Abstract

Hypothalamic hamartomas are benign tumors of low incidence, with epileptogenic characteristics, among which gelastic crises stand out. To date, there is no Gold Standard for the treatment of this type of pathology, there are multiple procedures, making it necessary to use a combined approach or surgery due to the recurrence of symptoms in several cases. In this study we describe our experience with a patient who was operated at different times and using different techniques to manage gelastic crisis with poor result. Disconnection of the epileptogenic area was proposed by performing several thermolesions using stereotactic radiofrequency. Control over time of gelastic seizures and a reduction in secondary seizures was observed, associated with low morbidity and mortality. It is proposed that radiofrequency is a good technique for this type of case due to its effectiveness, being minimally invasive and having a low associated risk.

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References

Kondajji AM, Evans A, Lum M, Kulinich D, Unterberger A, Ding K, Duong C, Patel K, Yang I. A systematic review of stereotactic radiofrequency ablation for hypothalamic hamartomas. J Neurol Sci. 2021; 15;(424):117428. doi: 10.1016/j.jns.2021.117428.

Scholly J, Staack AM, Kahane P, Scavarda D, Régis J, Hirsch E, Bartolomei F. Hypothalamic hamartoma: Epileptogenesis beyond the lesion? Epilepsia. 2017;58 Suppl 2:32-40. doi: 10.1111/epi.13755.

Rolston JD, Chang EF. Stereotactic Laser Ablation for Hypothalamic Hamartoma. Neurosurg Clin N Am. 2016 Jan;27(1):59-67. doi: 10.1016/j.nec.2015.08.007.

Bourdillon P, Ferrand-Sorbet S, Apra C, Chipaux M, Raffo E, Rosenberg S, Bulteau C, Dorison N, Bekaert O, Dinkelacker V, Le Guérinel C, Fohlen M, Dorfmüller G. Surgical treatment of hypothalamic hamartomas. Neurosurg Rev. 2021;44(2):753-762. doi: 10.1007/s10143-020-01298-z.

Kameyama S, Shirozu H, Masuda H, Ito Y, Sonoda M, Akazawa K. MRI-guided stereotactic radiofrequency thermocoagulation for 100 hypothalamic hamartomas. J Neurosurg. 2016;124(5):1503-12. doi: 10.3171/2015.4. JNS1582.

Wellmer J, Voges J, Parpaley Y. Lesion guided radiofrequency thermocoagulation (L-RFTC) for hypothalamic hamartomas, nodular heterotopias and cortical dysplasias: Review and perspective. Seizure. 2016;41:206-10. doi: 10.1016/j.seizure.2016.05.013.

Shirozu H, Masuda H, Kameyama S. Repeat stereotactic radiofrequency thermocoagulation in patients with hypothalamic hamartoma and seizure recurrence. Epilepsia Open. 2020 Jan 18;5(1):107-120. doi: 10.1002/epi4.12378.

Kuzniecky RI, Guthrie BL. Stereotactic surgical approach to hypothalamic hamartomas. Epileptic Disord. 2003;5(4): 275-80.

Parrent AG. Stereotactic radiofrequency ablation for the treatment of gelastic seizures associated with hypothalamic hamartoma. Case report. J Neurosurg. 1999;91(5):881-4. doi: 10.3171/jns.1999.91.5.0881.

Published

2024-12-09

How to Cite

1.
Menéndez R, Sánchez González F, Pampin S, Barbosa N, Quintanal Cordero NE, Piedimonte F. Stereotactic radiofrequency thermolesion for disconnection in Hypothalamic Hamartoma due to gelastic crises refractory to previous surgical interventions. NeuroTarget [Internet]. 2024 Dec. 9 [cited 2025 Feb. 5];18(1):57-61. Available from: https://neurotarget.com/index.php/nt/article/view/465

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Section

Case Report