Stimulation of the subthalamic region: Indications and results
DOI:
https://doi.org/10.47924/neurotarget2007380Keywords:
subthalamus, subthalamic nucleus, prelemniscal radiatons (RAPRL), deep brain stimulationAbstract
Parkinson´s disease is among the most frequent movement disorders. Patients otherwise refractory to medical therapy and with disabling symptoms are surgical candidates. Surgical applied anatomy of the subthalamic region is reviewed. Indications and results are presented and compared to those of the globus pallidus internus deep brain stimulation. Bilateral subthalamic nucleus stimulation improves motor fluctuations, dyskinesias and tremor. Postoperative programming is more time consuming with respect to a more recently proposed target, which is as useful as or even more effective than the nucleus for tremor control: The prelemniscal radiation. Adverse effects in both regions are usually reversible by adjusting stimulation parameters.
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DANE [Internet]. Bogotá, Colombia: Departamento Administrativo Nacional de Estadística de Colombia; 2007 [acceso 1 de julio de 2007]. Censo General 2005. Totales de Población. Disponible en: http://www.dane.gov.co/censo/files/presultados.pdf
Espinosa J. Enfermedad de Parkinson: Cirugía. Rev Asoc Colomb Gerontol Geriatr 2004;18:674-5.
Krack P, Batir A, Van Blercom N, Chabardes S, Fraix V, Ardouin C, et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med 2003;349(20):1925-34.
Velasco F, Jiménez F, Pérez ML, Carrillo-Ruiz JD, Velasco AL, Ceballos J, et al. Electrical stimulation of the prelemniscal radiation in the treatment of Parkinson's disease: an old target revised with new techniques. Neurosurgery 2001;49(2):293-306.
Arango G, Fernandez W, Rueda M, Espinosa J. Surgical Management of Parkinson´s disease. Deep brain stimulation of the Prelemniscal radiations. Mov Disord 2004;19 (suppl 9):S312.
Espinosa J, Arango G. Surgical management of Parkinson´s disease. Deep brain stimulation of the prelemniscal radiation. Mov Disord 2005;20 (suppl 10):S159-60.
Kitagawa M, Murata J, Uesugi H, Kikuchi S, Saito H, Tashiro K, et al. Two- year follow-up of chronic stimulation of the posterior subthalamic white matter for tremor-dominant Parkinson's disease. Neurosurgery 2005;56(2):281-9.
Hamani C, Saint-Cyr JA, Fraser J, Kaplitt M, Lozano AM. The subthalamic nucleus in the context of movement disorders. Brain 2004;127(Pt 1):4-20.
Mitrofanis J. Some certainty for the "zone of uncertainty"? Exploring the function of the zona incerta. Neuroscience 2005;130(1):1-15.
Hamel W, Schrader B, Weinert D, Müller D, Nedhorn HM. Hochfrequenzstimulation der Zona incerta: eine neue Zielstruktur zur Tiefenhirnstimulation bei Intentionstremor. [High frequency stimulation of the zona incerta; a new DBS target for intentional tremor]. Proceedings of the 52th Annual Meeting of the German Society of Neurosurgery; 2001 May 27-30; Bielefeld, Germany; 2001.
Parent A, Hazrati LN. Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res Brain Res Rev 1995;20(1):91-127.
Parent A, Hazrati LN. Functional anatomy of the basal ganglia. II. The place of subthalamic nucleus and external pallidum in basal ganglia circuitry. Brain Res Brain Res Rev 1995;20(1):128-54.
Rodriguez-Oroz MC, Rodriguez M, Guridi J, Mewes K, Chockkman V, Vitek J, et al. The subthalamic nucleus in Parkinson's disease: somatotopic organization and physiological characteristics. Brain 2001;124(Pt 9):1777-90.
Romanelli P, Esposito V, Schaal DW, Heit G. Somatotopy in the basal ganglia: experimental and clinical evidence for segregated sensorimotor channels. Brain Res Brain Res Rev 2005;48(1):112-28.
Krauss JK, Volkmann J. Tiefe Hirnstimulation. Darmstadt (Germany): Steinkopff Verlag; 2004.
Voges J, Volkmann J, Allert N, Lehrke R, Koulousakis A, Freund HJ, et al. Bilateral high-frequency stimulation in the subthalamic nucleus for the treatment of Parkinson disease: correlation of therapeutic effect with anatomical electrode position. J Neurosurg 2002;96(2):269-79.
Deuschl G, Schade-Brittinger C, Krack P, Volkmann J, Schäfer H, Bötzel K, et al.; German Parkinson Study Group, Neurostimulation Section. A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med 2006;355(9):896-908. Erratum in: N Engl J Med 2006;355(12):1289.
Rezai AR, Kopell BH, Gross RE, Vitek JL, Sharan AD, Limousin P, et al. Deep brain stimulation for Parkinson's disease: surgical issues. Mov Disord 2006;21 Suppl 14:S197-218.
Espinosa J. Neuroendoscopia y cirugía funcional. En: Burgos R, editor. Prácticas y procedimientos. Guías de Práctica Clínica. Neurocirugía. Bogotá (Colombia): Ediciones Médicas Latinoamericanas; 2003. p. 217-33.
Arango G, Espinosa J. Neuromodulación. En: Morillo L, editor. Guía Neurológica 7 Neuroelectrodiagnóstico. Bogotá (Colombia): Asociación Colombiana de Neurología; 2005. p. 211-20.
Espinosa J. Estimulación de la región subtalámica: Indicaciones y resultados. Neurociencias en Colombia 2006;14:51-8.
Walker AE. Normal and pathological physiology of the human thalamus. In: Schaltenbrand G, Walker AE, editors. Stereotaxy of the human brain: anatomy, physiological and clinical applications. 2nd ed. Stuttgart (Germany): Georg Thieme; 1982.
Nakano K, Kayahara T, Tsutsumi T, Ushiro H. Neural circuits and functional organization of the striatum. J Neurol 2000;247 Suppl 5:V1-15.
Middleton FA, Strick PL. Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Res Brain Res Rev 2000;31(2-3):236-50.
Espinosa J. Ganglios basales: Anatomía aplicada a cirugía funcional. Neurociencias en Colombia 2006;14:25-33.
Murata J, Kitagawa M, Uesugi H, Saito H, Iwasaki Y, Kikuchi S, et al. Electrical stimulation of the posterior subthalamic area for the treatment of intractable proximal tremor. J Neurosurg 2003;99(4):708-15.
Jiménez F, Velasco F, Velasco M, Brito F, Morel C, Márquez I, et al. Subthalamic prelemniscal radiation stimulation for the treatment of Parkinson's disease: electrophysiological characterization of the area. Arch Med Res 2000;31(3):270-81.
Barón L, Espinosa J. Las radiaciones prelemniscales y sus aplicaciones en el tratamiento del temblor en la Enfermedad de Parkinson: Indicaciones y resultados. Neurociencias en Colombia 2006;14:135-42.
Espinosa J. Manejo quirúrgico del temblor parkinsoniano y esencial con estimulación de las radiaciones prelemniscales. En: Resúmenes de Pre- sentaciones de la III Reunión Bianual de la SLANFE. Buenos Aires, Argentina; 21 de octubre 2006. Neurotarget 2006;1(2):66.
Carrillo-Ruiz J, Velasco F, Jiménez F, Hernández JA, Castro G, Velasco AL, et al. Efecto de la estimulación eléctrica bilateral de las radiaciones prelemniscales en la enfermedad de Parkinson. En: Resúmenes de Presentaciones de la III Reunión Bianual de la SLANFE. Buenos Aires, Argentina; 21 de octubre 2006. Neurotarget 2006;1(2):65.
Murata J, Kitagawa M, Uesugi H, Saito H, Iwasaki Y, Kikuchi S, et al. [Deep brain stimulation of the posterior subthalamic area (Zi/Raprl) for intractable tremor]. [Article in Japanese]. No Shinkei Geka 2007;35(4):355-62.
Micheli F, Cersósimo MG, Piedimonte F. Camptocormia in a patient with Parkinson disease: beneficial effects of pallidal deep brain stimulation. Case report. J Neurosurg 2005;103(6):1081-3.
Espinosa J. Manejo de complicaciones de estimulación cerebral profunda. En: Libro de Ponencias: XXXII Congreso Latinoamericano de Neurocirugía - CLAN 2006 y 39 Congreso Argentino de Neurocirugía; 21-26 de octubre. Buenos Aires, Argentina: Asociación Argentina de Neurocirugía. Revista Argentina de Neurocirugía 2006;20 Suppl 1:S33.
Kenney C, Simpson R, Hunter C, Ondo W, Almaguer M, Davidson A, et al. Short-term and long-term safety of deep brain stimulation in the treatment of movement disorders. J Neurosurg 2007;106(4):621-5.
Hilker R, Portman AT, Voges J, Staal MJ, Burghaus L, van Laar T, et al. Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation. J Neurol Neurosurg Psychiatry 2005;76(9):1217-21.
Deep-Brain Stimulation for Parkinson's Disease Study Group. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl J Med 2001;345(13):956-63.
Anderson VC, Burchiel KJ, Hogarth P, Favre J, Hammerstad JP. Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease. Arch Neurol 2005;62(4):554-60.
Cersosimo MG, Piedimonte F, Raina GB, Micheli FE. Bilateral STN-DBS fails to improve non-motor fluctuations in a PD patient. Parkinsonism Relat Disord 2007 Jan 18; [Epub ahead of print]
Lombardi WJ, Gross RE, Trepanier LL, Lang AE, Lozano AM, Saint-Cyr JA. Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease: support for the existence of cognitive circuits in the human pallidum. Brain 2000;123 (Pt 4):746-58.
Mallet L, Schüpbach M, N'Diaye K, Remy P, Bardinet E, Czernecki V, et al. Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior. Proc Natl Acad Sci U S A 2007;104(25):10661-6.
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Copyright (c) 2007 Jairo Espinosa Martínez
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