Predicción del efecto analgésico de la oxicodona por medio de pruebas sensoriales cuantitativas «estáticas» y «dinámicas» en sujetos sanos.: Publicado previamente en la Revista PAIN®2010;151:104-9.

Elon Eisenberg; Ayelet Midbari; May Haddad; Dorit Pudd

doi:10.47924/neurotarget2011277

Authors

Elon Eisenberg The Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Israel.
Ayelet Midbari Pain Relief Unit, Rambam Medical Center, Haifa, Israel.
May Haddad Anesthesiology Department, Rabin Medical Center, Israel.
Dorit Pudd Faculty of Social Welfare and Health Sciences, University of Haifa, Israel.

DOI:

https://doi.org/10.47924/neurotarget2011277

Keywords:

Cold pressor test (CPT), diffuse noxious inhibitory control (DNIC), opioid analgesia, quantitative sensory testing (QST), temporal summation, thermal pain threshold

Abstract

The large inter-individual variability in the magnitude of analgesia in response to opioids and the high prevalence of adverse events associated with their use underline the clinical importance of being ableto predict who will or will not respond to opioid treatment. The present study used both static and dynamic quantita- tive sensory testing (QST) on 40 healthy volunteers in order to test whether this methodologycan predict the analgesic effects of oral oxycodone, as compared to a placebo, on latency to onset, pain intensity, and tolerance to the cold pressor test (CPT). Static QST consisted of measuring heat and cold pain thresh- olds. Dynamic QST included measurements of the magnitude of the diffuse noxious inhibitory control (DNIC)-like effect and of temporal summation (TS). Results showed that oxycodone, but not the placebo, significantly elevated the latency and tolerance to cold pain and significantly reduced pain intensity.

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