Excitabilidad Cortical por Estimulación Magnética Transcraneal como Biomarcadores para el Control de las Convulsiones en Epilepsia del Lóbulo Temporal.: Publicado originalmente en la Revista Neuromodulation 2020; 23: 399–406.  Traducción: Dra. Luciana Caramuta.

Han-Wei Huang; Jing-Jane Tsai; Pei-Fang Su; Yu-Lin Mau; Yi-Jen Wu; Wen-Chi Wang; Chou-Ching K Lin

doi:10.47924/neurotarget202121

Authors

Han-Wei Huang Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jing-Jane Tsai Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Pei-Fang Su Department of Statistics, College of Management, National Cheng Kung University, Tainan, Taiwan.
Yu-Lin Mau Department of Statistics, College of Management, National Cheng Kung University, Tainan, Taiwan.
Yi-Jen Wu Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wen-Chi Wang Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chou-Ching K. Lin Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. https://orcid.org/0000-0002-3070-5787

DOI:

https://doi.org/10.47924/neurotarget202121

Keywords:

Cortical excitability, intracortical facilitation, long-interval intracortical inhibition, short-interval intracortical inhibition, temporal lobe epilepsy, transcranial magnetic stimulation

Abstract

Objective: To investigate whether indicators of cortical excitability are good biomarkers of seizure controllability in temporal lobe epilepsy (TLE).
Materials and Methods: Three groups of subjects were recruited: those with poorly controlled (PC) TLE (N = 41), well controlled (WC) TLE (N = 71), and healthy controls (N = 44). Short- and long-latency recovery curves were obtained by paired pulse transcranial magnetic stimulation. Linear mixed effect models were used to study the effects of group, interstimulus interval (ISI), and antiepileptic drugs on long-interval intracortical inhibition (LICI) and short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF).
Results: The mixed effect model that did not incorporate antiepileptic drugs showed that group and ISI were significant factors for LICI and SICI/ICF. LICI in the healthy control group was greater than in the two epilepsy groups, and the difference was significant at ISIs of 50, 150, and 200 msec. In contrast, SICI/ICF in the PC group was greater than in the healthy control and WC groups, and the difference was significant at an ISI of 15 msec. However, due to large variance, it was difficult to identify a cutoff value with both good sensitivity and good specificity. Incorporating the information of antiepileptic drugs to the mixed effect model did not change the overall results.
Conclusions: Although LICI and SICI/ICF parameters were significantly different at the group level, they may not be suitable biomarkers for the controllability of TLE at the subject level.

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