Patrones de prescripción y efecto de la artroplastía total de cadera sobre el uso de analgésicos, hipnóticos, antidepresivos y ansiolíticos: resultados de una población de pacientes sometidos a artroplastia total de cadera.: Artículo publicado originalmente en la revista PAIN 2016; 157(3): 643-651. Traducción: Tania Acosta.

Tone Blagestad; Inger H. Nordhusa; Janne Grønli; Lars B. Engesæter; Sabine Ruths; Anette H. Ranhoff; Bjørn Bjorvatng; Stale Pallesenl

doi:10.47924/neurotarget2016175

Authors

Tone Blagestad Department of Clinical Psychology, University of Bergen, Bergen, Norway.
Inger H. Nordhusa Department of Behavioral Sciences in Medicine, University of Oslo, Oslo, Norway.
Janne Grønli Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway and Sleep and Performance Research Center, College of Medical Sciences, Washington State University, Spokane, WA, USA.
Lars B. Engesæter Department of Clinical Medicine, University of Bergen, Bergen, Norway and Department of Orthopedics, Haukeland University Hospital, Bergen, Norway.
Sabine Ruths Departamento de Salud Pública Mundial y Atención Primaria, Universidad de Bergen, Bergen, Noruega y Unidad de Investigación para la Práctica General, Uni Research Health, Bergen, Noruega.
Anette H. Ranhoff Kavli Research Center for Aging and Dementia, Haraldsplass Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway and Diakonhjemmet Hospital, Oslo, Norway.
Bjørn Bjorvatng Centro Noruego de Competencia para los Trastornos del Sueño, Hospital Universitario de Haukeland, Bergen, Noruega.
Stale Pallesenl Department of Psychosocial Science, University of Bergen, Bergen, Norway.

DOI:

https://doi.org/10.47924/neurotarget2016175

Keywords:

Register study, Total hip arthroplasty, Analgesics, Psychotropics

Abstract

Total hip arthroplasty (THA) has been shown to reduce pain and improve function. In addition, it is suggested that THA improves sleep and alleviates symptoms of anxiety and depression. Patients with chronic pain are frequent users of analgesic and psychotropic drugs and thereby risk adverse drug events. The impact of THA on such drug use has not been thoroughly investigated. Based on merged data from the Norwegian Prescription Database and the Norwegian Arthroplasty Register, this study sought to investigate redeemed medications in a complete population (N539,688) undergoing THA in 2005 to 2011. User rates and redeemed drug volume of analgesics (nonsteroid anti-inflammatory drugs (NSAIDs), opioids, and nonopioids) and psychotropics (hypnotics, anxiolytics, and antidepressants) were calculated for 4 quarters before and 4 quarters after surgery. We analysed preoperative prescription trends (Q1 vs Q4), postoperative prescription (Q4 vs Q5), and long-term effect of surgery (Q4 vs Q8). Before surgery, use of all drug groups increased from Q1 to Q4. Use of opioids, nonopioids, and hypnotics dramatically increased from Q4 to Q5. Long-term (Q4 vs Q8) surgery reduced prescriptions of analgesics, hypnotics, and anxiolytics, but not antidepressants. Overall, the present results extend the positive effects of THA to include reduced reliance on medication to alleviate symptoms.

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