Neurobiología de la depresión.
DOI:
https://doi.org/10.47924/neurotarget201950Palabras clave:
depresión, neurobiología, estrésResumen
Se ha demostrado que el estrés juega un rol crucial en el origen y desarrollo de la depresión. En ese sentido, se puede afirmar que es el resultado de la interacción entre diferentes factores convergentes. Entre ellos, se ha demostrado aumento en los niveles de factor liberador de corticotrofina y cortisol, aumento en la actividad de la amígdala, disminución en la actividad del hipocampo, disminución en la neurotransmisión serotoninérgica, todo lo cual conduce al desarrollo de la depresión. La presencia de ciertos polimorfismos genéticos y mecanismos epigenéticos representan factores de vulnerabilidad biológica. De esta manera, estudios orientados a identificar y comprender los mecanismos que subyacen a los diferentes factores de vulnerabilidad y sus posibles interacciones podrán permitir el desarrollo de nuevos abordajes de tratamiento y prevención de la depresión, particularmente en aquellas personas más vulnerables.
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Derechos de autor 2019 Leandro Piedimonte, DM Flores Helguero, A. López Mato, GE Tafet
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
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